Wednesday, August 24, 2011
Monday, July 4, 2011
"Ours is a government of the people. It represents their will. Its officers may sometimes go astray, but that is not a reason for criticizing the principles of our institutions. The real heart of the American Government depends upon the heart of the people. It is from that source that we must look for all genuine reform. It is to that cause that we must ascribe all our results.
It was in the contemplation of these truths that the fathers made their declaration and adopted their Constitution. It was to establish a free government, which must not be permitted to degenerate into the unrestrained authority of a mere majority or the unbridled weight of a mere influential few. They undertook the balance these interests against each other and provide the three separate independent branches, the executive, the legislative, and the judicial departments of the Government, with checks against each other in order that neither one might encroach upon the other. These are our guaranties of liberty. As a result of these methods enterprise has been duly protected from confiscation, the people have been free from oppression, and there has been an ever-broadening and deepening of the humanities of life...
No other theory is adequate to explain or comprehend the Declaration of Independence. It is the product of the spiritual insight of the people. We live in an age of science and of abounding accumulation of material things. These did not create our Declaration. Our Declaration created them. The things of the spirit come first. Unless we cling to that, all our material prosperity, overwhelming though it may appear, will turn to a barren sceptre in our grasp. If we are to maintain the great heritage which has been bequeathed to us, we must be like-minded as the fathers who created it. We must not sink into a pagan materialism. We must cultivate the reverence which they had for the things that are holy. We must follow the spiritual and moral leadership which they showed. We must keep replenished, that they may glow with a more compelling flame, the altar fires before which they worshiped."
Read the whole thing here. Its significantly longer and much better than a tweet.
Thursday, June 30, 2011
...thanks to collaborative work involving the laboratory of Neil Simister,an associate professor of molecular biology at Brandeis, and doctors at Children’s Hospital and Brigham and Women’s Hospital, hemophilia patients may soon have access to long-acting clotting medications that free them from the hassles of frequent infusions and from worries that an internal bleed has gone unnoticed.
Simister’s laboratory, as well as labs at the University of Texas and Ohio State University, independently and simultaneously discovered that the receptor FcRn protects antibodies from breaking down in the body. Building on that basic discovery has enabled the formulation of new hemophilia drugs.
...estimates that they are probably less than 12 months away from getting definitive Phase III results for both hemophilia A and B programs. The next step would be filing for FDA approval.
Original article here.
Wednesday, June 29, 2011
Monday, June 20, 2011
ANNAPOLIS, Md., June 15, 2011 /PRNewswire/ -- PPTA opposes New Jersey Assembly Bill 2003 passed by the New Jersey Assembly Appropriations Committee on June 13 that imposes a new tax on therapies used to treat bleeding disorders like hemophilia.
The bill creates The Bleeding Disorders Treatment Fund by taxing the manufacturers of blood clotting factor in the form of a 6 percent rebate. PPTA opposes any policy that would impose a tax on the sale of lifesaving therapies. PPTA calls on the pharmaceutical industry at large to keep a close watch on this bill, which is a slippery slope towards taxing other medicines.
Friday, June 17, 2011
Friday, June 3, 2011
-Sangamo scientist Michael Holmes presented data from a study in mice which showed encouraging results in a specific type of hemophilia. In this case, the disease comes from a deficiency of a protein know as Factor IX. Scientists gave a single injection of one of Sangamo's zinc-finger compounds and found that mice who got the injection were able to produce Factor IX on their own in high enough levels to achieve normal blood clotting...Original article from Xconomy.com
Friday, May 1, 2009
Not affiliated with the Tolkien estate or Peter Jackson or New Line Cinema "The Hunt for Gollum" is a not for profit short film made by fans of the author's work. It's set for release on May 3rd.
I only just came across its existence but from the trailers it looks way cool. The story comes from the appendices of The Lord of the Rings. The appendices have so much background material that many more shorts or even features could be made from them. And that's not even getting into the epic Silmarillion (which is rumoured to be in the early stages of a film adaptation).
Here's the original Trailer:
Wednesday, March 18, 2009
One noteable news item with an Ireland tie-in.
Steelers owner is Ireland nominee
6-time Super Bowl Champion Pittsburgh Steelers owner Dan Rooney has been selected to be U.S. ambassador to Ireland by President Barack Obama.
My dad went school with the Rooney boys, North Catholic High School in Pittsburgh and St. Vincent's College in Latrobe. I believe Art Jr. was in dad's class and Dan was a couple years
Well wouldn't you know it. First post after a long layoff and kinda I blow it. The Rooney's went to North Catholic, but only Art Jr. went on to St. Vincent's. Dan went to Duquesne.
Friday, March 13, 2009
Tuesday, December 30, 2008
I fear in my case it's just been plain lazy. A lot has happened recently but I haven't felt compelled to write. I hope to do better in the new year.
Best wishes to all for 2009.
Wednesday, November 19, 2008
According to a Children's Hospital of Wisconsin press release researchers there have shown success using patients' bone marrow to treat inhibitors.
The findings were published in the 1 October 2008 issue of Blood Journal.
From the press release:
"...investigators describe how a gene-modified bone marrow transplant can be used to initiate clotting in hemophilia. This type of approach may work in the 30 to 35 percent of hemophilia patients that have developed inhibitory antibodies against the missing clotting protein.
The bone marrow is removed from the patient and stem cells are treated with Factor VIII, a clotting factor, which is placed in the platelets. The marrow is given back to the patient, who then retains the essential clotting mechanisms to stop bleeding that otherwise would lead to complications."
In 2 1/2 minutes Lincoln conveyed just how unique, precious and fragile the United States of America was, is and will be. But inherent in its foundation is the principle of Liberty and the notion that "all men are created equal" that make it a concept embodied in a nation that is worth preserving, defending and dying for.
The words ring as true today are they did then.
Four score and seven years ago our fathers brought forth on this continent, a new nation, conceived in Liberty, and dedicated to the proposition that all men are created equal.
Now we are engaged in a great civil war, testing whether that nation, or any nation so conceived and so dedicated, can long endure. We are met on a great battle-field of that war. We have come to dedicate a portion of that field, as a final resting place for those who here gave their lives that that nation might live. It is altogether fitting and proper that we should do this.
But, in a larger sense, we can not dedicate -- we can not consecrate -- we can not hallow -- this ground. The brave men, living and dead, who struggled here, have consecrated it, far above our poor power to add or detract. The world will little note, nor long remember what we say here, but it can never forget what they did here. It is for us the living, rather, to be dedicated here to the unfinished work which they who fought here have thus far so nobly advanced. It is rather for us to be here dedicated to the great task remaining before us -- that from these honored dead we take increased devotion to that cause for which they gave the last full measure of devotion -- that we here highly resolve that these dead shall not have died in vain -- that this nation, under God, shall have a new birth of freedom -- and that government of the people, by the people, for the people, shall not perish from the earth.
Saturday, November 8, 2008
Since I was there I took extra time (a week) to travel a bit and saw some amazing sites. I am so glad to have made the trip but truth be told I don't ever want to be away from Allison and the boys for that long again.
Here's some more pics from Israel:
Jaffa Gate - Jerusalem Old City
Church of the Holy Sepulchre - site of the Crucifixion
Church of the Holy Sepulchre - Edicule - Christ's tomb
The Western Wall
Tuesday, October 28, 2008
Here's some Israel pics.
Site of the Nativity in the Church of the Nativity
Dig site in Jericho
Friday, October 17, 2008
Wednesday, October 15, 2008
A lawsuit against the Tecumseh school district and an elementary teacher over bullying injuries a first-grade student with hemophilia suffered in 2005 was tossed out of Lenawee County Circuit Court on Monday.
Man! First of all bullying injuries in first grade! Hemophilia or not what the ...?
From the report:
Michael suffered severe injuries when his arm was twisted behind his back...
Now we can't know all the details from just a news article but what's going on. I'm not sure these incidents called for a lawsuit but certainly they raise some questions about the supervision or discipline at the school, child with hemophilia or not.
As parents of a child with hemophilia we strive to emphasize that Jack is not to be treated differently or excluded from school activities. He doesn't need special attention save in the event
that an injury does happen and then he needs specific medical treatment.
So with that in mind these comments (for the purpose of a lawsuit!) stung:
“They knew he had severe hemophilia. They knew they had to protect him,” argued Hanson’s attorney, James Cmejrek. Although the teacher was not in the lunch room where the second injury occurred, Cmejrek said she failed to instruct lunch room monitors to give Michael special protection because of his condition... (italics mine)
"Administering Kogenate FS to children with hemophilia A on a daily basis before a bleeding event occurs will reduce bleeding into joints and help prevent joint damage, a major cause of disability in hemophiliacs," said Dr. Jesse Goodman, director of the agency's Center for Biologics Evaluation and Research. (italics mine)
Nice bit of marketing juice for Bayer's Kogenate FS. But perhaps an underlying benefit is to signal an acknowledgement for insurers that a robust prophylactic regime should be fully embraced and properly covered.